See the best Marvel Avengers cosplay from San Diego Comic-Con 2019 AVENGERS ASSEMBLE! Bring home Marvel Studios’ @Avengers: Endgame on Digital July 30 and Blu-ray August 13: https://t.co/6wVet96bw0 pic.twitter.com/luboLlLCvL— Marvel Studios (@MarvelStudios) June 26, 2019 Share your voice Comments Now playing: Watch this: 30 Photos TVs Blu-ray Players Media Streamers TV and Movies Avengers: Endgame could have been very different Amazon Fire TV Note that CNET may get a share of revenue from the sale of merchandise featured on this page. Getting a disc or digital version with the directors’ commentary and deleted scenes will shed some new light on the movie, even for hardcore Marvel fans. See Avengers: Endgame (plus bonus features) at AmazonAlso notable for the home release is that Endgame is one of the first movies to support Dolby Vision and Dolby Atmos on the Movies Anywhere service — at least when viewed on 4K-capable Apple TV, Fire TV, Chromecast and Android TV hardware on compatible 4K TVs. Those premium HDR video and surround audio features will also be retroactively added to some previous 4K Movies Anywhere releases throughout the summer and fall. See Avengers: Endgame in 4K HDR at Movies AnywhereBefore you plunk down more cash to see it again, however, keep in mind it’s also slated to hit the Disney Plus streaming service on Dec. 11. That online channel arrives in November and will cost $7 per month. Avengers: Endgame takes disc form today. Marvel Studios The humble Blu-ray disc hasn’t been Thanos’d yet. Avengers: Endgame, the biggest movie in the world, hit stores today on Blu-ray, UHD 4K and DVD, joined by a handful of older Marvel films.Avengers: Endgame is now available at most outlets for $22.99 (1080p), $29.99 (UHD 4K Blu-ray). Best Buy has an exclusive SteelBook version for $34.99 — basically, a fancy case — while Target has a version with an exclusive book — Avengers Initiative: The First 10 Years — for the same price.The release of Endgame is accompanied by five other remastered Marvel titles on UHD 4K Blu-ray — Iron Man, Iron Man 2, Iron Man 3, Thor, and Thor: The Dark World — with more expected soon.See Avengers: Endgame SteelBook Edition at Best BuyThe $20 digital version of Endgame was released earlier this month on sites such as Amazon, iTunes and Vudu. In July, Endgame surpassed Avatar as the highest-grossing movie of all time, thanks in part to a theatrical re-release in recent weeks that included a post-credits scene and Stan Lee tribute. Marvel Thor Amazon Iron Man 3 News • Apple Music is now available on Amazon Fire TV Review • Amazon Fire TV: Affordable Alexa-infused 4K streaming Tags 2:00
© 2018 Phys.org The skeleton (right) excavated at the St. Nikolay Church in Oslo, which carried sequences for the pathogen of louse-borne relapsing fever. Credit: PNAS Citation: Genetic study of 15th century samples shows adaptive changes in bacteria that cause relapsing fever (2018, September 25) retrieved 18 August 2019 from https://phys.org/news/2018-09-genetic-15th-century-samples-bacteria.html More information: Meriam Guellil et al. Genomic blueprint of a relapsing fever pathogen in 15th century Scandinavia, Proceedings of the National Academy of Sciences (2018). DOI: 10.1073/pnas.1807266115 Journal information: Proceedings of the National Academy of Sciences Explore further Gene study pinpoints superbug link between people and animals Relapsing fever, as its name implies, is an ailment whereby an infected person experiences a fever several times following a single infection. If untreated, it is fatal in 10 out of 40 cases. It is transmitted by fleas and lice. Back in the 15th century, it was responsible for killing millions of people in Europe—today, it is mostly confined to several countries in Africa. In this new effort, the researchers conducted a genetic analysis of the bacteria that caused the disease 600 years ago and compared it to bacteria causing the same disease today. Samples of Borrelia recurrentis were retrieved from skeletons excavated from St. Nikolai Cemetery in Old Oslo—they have been dated to between 1430 and 1465.After generating a genetic assembly, the researchers compared it with genetic assemblies created by prior researchers studying the genome of the modern form of the bacteria. This allowed them to see how the bacteria has evolved over time.The researchers report that they were able to sequence approximately 17 percent of the bacterial genome from skeletal bones which they bolstered by sequencing samples taken from teeth. Using data from both, they were able to sequence approximately 98.2 percent of the main chromosome. Comparing the findings with modern strains, they found that the earlier strains lacked three variable short protein genes and one plasmid found on modern strains. Prior research has shown that the proteins act as proinflammatory agents for the bacteria, which, the researchers note, are key elements of the relapsing nature of the disease. They note further that such changes likely account for the differences in relapse rates—the disease tended to relapse just once or twice back in the 1400s, but is known to relapse up to five times in people afflicted today. A team of researchers with members from the University of Oslo and the Norwegian Institute for Cultural Heritage Research has conducted a genetic analysis of the bacteria that causes relapsing fever obtained from 15th century skeletons in Norway. In their paper published in Proceedings of the National Academy of Sciences, the group describes their study and what they found when they compared their results with the genome of modern bacteria. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.